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Türkçe > İngilizce İngilizce > Türkçe
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Türkçe > İngilizce: Arotomaz Eksikliği General field: Tıp Detailed field: Tıp (genel)
Kaynak metin - Türkçe Aromotaz eksikliği ve aromotaz gen mutasyonu ilk kez bir erkek olguda 1995 yılında otozomal resesif bir hastalık olarak tanımlandı(6). 1995, 2010 yılları arasında sekiz yeni erkek olgu bildirildi. Aromotaz eksikliği nadir görülen bir sendrom olup, CYP19A1 gen mutasyonu sonucu aromotaz disfonksiyonuna bağlı estrojen sentezi azalır. Östrojenin, kadın reprodüktif sistemi üzerindeki etkisi uzun yıllardır bilinmektedir, fakat kadın ve erkekte estrojenin reprodüktif sistem dışı etkileri yakın zamanda tanımlandı(3). Özellikle östrojenin erkek reprodüktif sistemi üzerindeki etkileri üzerinde son 10 yıldır durulmaktadır(4). Puberta sırasında büyüme ve kemik maturasyonu her iki cinsiyettede androjene bağlı olur. Androjen erkekte aromotaz ile östrojene dönüşür. Puberta sırasında artan androjenlere bağlı östrojen seviyesi artar, sonuçta kemik maturasyonu, epifizyal kartilajda ossifikasyon gelişir(5). Aromotaz eksikliği sendromunda, estojen eksikliğine bağlı her iki cinsiyette gecikmiş epifizyal kapanma, önikoid vücut yapısı, osteopeni ve oteoporoz gelişir(2).
Çeviri - İngilizce The aromatase deficiency and aromatase gene mutation were first defined in 1995 at a male subject as an autosomal recessive disorder (6). Eight new male subjects were reported between the years 1995 and 2010. The deficiency of aromatase is a rare syndrom resulting in decreased estrogen synthesis due to aromatase disfunction as a consequence of CYP19A1 gene mutation. The effects of estrogen other than reproductive system on both male and female subjects have recently been discovered (3) while its effect on female reproductive system being known for many years . In the past decade, it has been focused on the effects of estrogen on particularly male reproductive system (4). Growth and bone maturation during puberty depend on androgen in both genders and androgen is converted into estrogen in males in the presence of aromatase. During puberty, the estrogen level is increased with an increased level of androgen resulted in bone maturation and ossification of epiphyseal cartilages (5). Delayed epiphyseal closure, onychoid body structure, osteopenia and osteoporosis disorders are developed during aromatase deficiency syndrom in both genders resulting from estrogen deficiency (2).
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Çeviri eğitimi
Bachelor's degree - Karadeniz Teknik University
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Deneyim (yıl): 21. ProZ.com’a kayıt tarihi: Jan 2017.
I am a Turkish native speaker and working as an English Lecturer at Mugla Sıtkı Koçman University in Turkey. I have 12 years of Professional experience . I have A BA degree . I did alot of translations nearly on all kinds of subjects and fields. I am willing to apply for your job. I attach my resume. Thanks .
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