Jan 19, 2018 09:01
6 yrs ago
English term
beta-deletion transcript
English to Russian
Science
Biology (-tech,-chem,micro-)
beta-deletion transcript
This gene is involved in splicing of the beta-deletion transcript of hTERT
Proposed translations
(Russian)
4 | сплайсинг транскрипта hTERT с бета-делецией | Natalie |
3 | продукт транскрипции с бета-делецией | Maksym Nevzorov |
Proposed translations
2 hrs
Selected
сплайсинг транскрипта hTERT с бета-делецией
Или - сплайсинг бета-делеционного варианта hTERT, как на http://www.fesmu.ru/elib/Article.aspx?id=315940
Англ объяснение: https://www.ncbi.nlm.nih.gov/pubmed/12869302
Англ объяснение: https://www.ncbi.nlm.nih.gov/pubmed/12869302
4 KudoZ points awarded for this answer.
Comment: "Спасибо!"
2 hrs
продукт транскрипции с бета-делецией
Вероятно, "бета-" здесь указывает на один из возможных участков hTERT, в котором может происходить делеция, потому что встречается упоминание альфа- и бета-делеций вот такого вида:
https://www.ncbi.nlm.nih.gov/pubmed/11191110
An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity.
Yi X1, White DM, Aisner DL, Baur JA, Wright WE, Shay JW.
The telomerase transcript has been shown to have at least six alternate splicing sites (four insertion sites and two deletion sites), and variants containing both or either of the deletion sites are present during development and in a panel of cancer cell lines we surveyed. One deletion (beta site) and all four insertions cause premature translation terminations, whereas the other deletion (alpha site) is 36 bp and lies within reverse transcriptase (RT) motif A, suggesting that this deletion variant may be a candidate as a dominant-negative inhibitor of telomerase. We have cloned three alternately spliced hTERT variants that contain the alpha, beta or both alpha and beta deletion sites.
https://www.ncbi.nlm.nih.gov/pubmed/11191110
An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity.
Yi X1, White DM, Aisner DL, Baur JA, Wright WE, Shay JW.
The telomerase transcript has been shown to have at least six alternate splicing sites (four insertion sites and two deletion sites), and variants containing both or either of the deletion sites are present during development and in a panel of cancer cell lines we surveyed. One deletion (beta site) and all four insertions cause premature translation terminations, whereas the other deletion (alpha site) is 36 bp and lies within reverse transcriptase (RT) motif A, suggesting that this deletion variant may be a candidate as a dominant-negative inhibitor of telomerase. We have cloned three alternately spliced hTERT variants that contain the alpha, beta or both alpha and beta deletion sites.
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