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n- dealkylated

English translation: N-dealkylated

16:17 Jul 16, 2008
English language (monolingual) [PRO]
Medical - Medical: Pharmaceuticals
English term or phrase: n- dealkylated
current studies are focusing on norbuprenorphine, an N- dealkylated metabolite of buprenorphine
MARIBEL GARCIA
Selected answer:N-dealkylated
Explanation:
Buprenorphine contains one Nitrogen atom (the N should be capitalized) which contains an alkylgroup. It is metabolised in the liver by an enzyme to norbuprenorphine, which contains a Proton instead of the Alkylgroup. Therefore, norbuprenorphine is also called the N-dealkylated metabolite of buprenorphine since the Nitrogen atom was dealkylated (removal of the alkylgroup).
Selected response from:

Sabine Akabayov, PhD
Israel
Local time: 16:15
Grading comment
Selected automatically based on peer agreement.
4 KudoZ points were awarded for this answer



SUMMARY OF ALL EXPLANATIONS PROVIDED
4 +5N-dealkylated
Sabine Akabayov, PhD
4n- dealkylated
Elena Petelos


  

Answers


7 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5
n- dealkylated


Explanation:
Name of the newly generated compound, after the removal of alkyl groups from the compound. (N-alkyl group(s), etc.




    Reference: http://www.google.co.uk/search?hl=el&rlz=1T4GGLJ_enGR210GR21...
Elena Petelos
United Kingdom
Local time: 14:15
Specializes in field
Native speaker of: Greek
PRO pts in category: 4
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2 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +5
N-dealkylated


Explanation:
Buprenorphine contains one Nitrogen atom (the N should be capitalized) which contains an alkylgroup. It is metabolised in the liver by an enzyme to norbuprenorphine, which contains a Proton instead of the Alkylgroup. Therefore, norbuprenorphine is also called the N-dealkylated metabolite of buprenorphine since the Nitrogen atom was dealkylated (removal of the alkylgroup).

Sabine Akabayov, PhD
Israel
Local time: 16:15
Specializes in field
Native speaker of: Native in GermanGerman
PRO pts in category: 4
Grading comment
Selected automatically based on peer agreement.

Peer comments on this answer (and responses from the answerer)
agree  Demi Ebrite
57 mins
agree  Jean-Louis S.
1 hr
agree  BdiL: In other words (besides the impeccable chemical explanation) "N-dealkylated" is tantamount to an adjective meaning "with one Nitrogen that has undergone a dealkylation process" or "lost an alkyl group". Maurizio
3 hrs
agree  Jörgen Slet
1 day 13 hrs
agree  Phong Le
2 days 18 hrs
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