English to Russian Medical Medical: Pharmaceuticals

Minimum of 36 evaluable subjects for each group would provide 85% power to detect a treatment effect of 65% or more reduction in the cumulative number of new gadolinium-enhancing T1 lesions in an orelabrutinib treatment group compared to the placebo group, using the restricted maximum likelihood estimation variance calculation method at a two-sided significance level of 5% and assuming a negative binomial distribution with dispersion parameter = 1.