Giovanni Rengifo Apr 16, 2020:

@Neil I think you're right. They're probably speaking of "lab test results" here.

Chema Nieto Castañón Apr 16, 2020:

@Neil the label "lab adverse event" is applied if any lab value exceeds the inclusion threshold and is associated with a variation from baseline exceeding the variation threshold defined from reference change limit. 
https://pubmed.ncbi.nlm.nih.gov/9174675/

This is, a lab adverse event is defined by lab values exceeding certain variation thresholds. And so not just any but only certain abnormal lab results (selected by relevance or specified thresholds) will define a lab adverse event.

And so there is no chicken-or-egg; a "lab adverse experience" [event] cannot be read just as an "abnormal lab result"; to become an "event" it must conform to certain characteristics or relevance. When translating thus "lab adverse event", the translation must convey "adverse event" ("evento adverso") rather than "abnormal lab result" ("alteraciones analíticas"). And I have already discussed why "de laboratorio" rather than "analítica" seems more suitable in this case, which hopefully makes the translation into Spanish quite straightforward.

liz askew Apr 16, 2020:

= laboratory-based adverse events

https://www.researchgate.net/figure/Example-of-laboratory-ba...

liz askew Apr 16, 2020:

https://books.google.co.uk/books?id=YTlDBEL2FyIC&pg=PA89&lpg...

liz askew Apr 16, 2020:

Here is an example;
https://www.researchgate.net/figure/Overall-summary-of-clini...

Chema Nieto Castañón Apr 16, 2020:

@Teresa Aunque Neil ciertamente apunta en la dirección correcta, no se trata sin más de alteraciones analíticas sino de eventos adversos definibles en base a criterios analíticos ("de laboratorio" versus clínicos). Para mí, la forma más natural de expresarlo, por analogía con "eventos clínicos adversos", sería "eventos analíticos adversos", pero cierto es que los estudios microbiológicos por ejemplo no son "analíticas" en sentido estricto, y de ahí que se haga referencia a "de laboratorio" ("eventos adversos de laboratorio") antes que a "analíticos" ("eventos analíticos adversos"), creo que correctamente y con fundamento, y no como mera expresión literal de su equivalente inglés en este caso.

Neil Ashby Apr 15, 2020:

Giovanni - I think "laboratory" here means lab tests, really it should be something like "altered/abnormal analytical results" - in fact, I'm going to put it in a suggestion ;@)

Giovanni Rengifo Apr 15, 2020:

@Fernanda I think you're right about translating "experiences" with "eventos" here. That's the term that I'm famililar with when it comes to clinical trials where they usually speak of "serious adverse events." Since this is a human clinical trial, I don't understand why they're using the word "laboratory". In my opinion, it doesn't make any sense. Wouldn't that be "in vitro"? Anyway, I'd like to hear what our colleagues have to say about this. Additionally, I think they could also mean "outcomes" (desenlaces) here. Was the source text originally written in English or is it a translation from another language?